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  1. Flights
  2. Panama
  3. Panama City
  4. Santo Domingo - Panama City

Flights from Santo Domingo to Panama City

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Explore the best deals

Discover the cheapest flights from Santo Domingo to Panama City
Thu, Dec 10
AV
AVDirect
SDQ - PTY
286€
275€
Prime price per passenger
Wed, Nov 25
AV
AVDirect
SDQ - PTY
300€
288€
Prime price per passenger
The prices shown on this page were available within the last 20 days for the specified periods and should not be considered the final price offered. Please note that availability and prices are subject to change.

Cheapest time to fly from Santo Domingo to Panama City

If you’re planning to fly this route soon, keep in mind that the lowest fares are usually available in the middle of November. Take advantage of this period to save on your flight tickets and make the most of your trip. Please note that prices may change after your search.
Filter by
week: Dec 7 - Dec 13
Flights from just €383
€537
€383
€506
€435
NovemberDecemberJanuary
Airlines that fly from Santo Domingo to Panama City
Copa Airlines
Copa Airlines
504€
Avianca
Avianca
543€
Distance: 1,480 km
Santo Domingo airports
Las Americas International Airport (SDQ)How far from city centre: 24 km
Panama City airports
Tocumen International Airport (PTY)How far from city centre: 3 km

Book your flight from Santo Domingo to Panama City

Find direct and indirect flights from Santo Domingo to Panama City (Panama) with eDreams. Once you have your results, sort them by schedule or price and book the option that best suits your plans.

The lowest fare booked on this route in recent days was €275, though the price you see will depend on your travel dates and departure times.

A direct flight from Santo Domingo to Panama City takes around 4 h and 30 m, while indirect flights will take longer.

Airports and airlines connecting Santo Domingo and Panama City

Knowing where you set off from and where you arrive helps you organise your journey better. Consider the available airports and compare the different airlines operating on this route.

  • Departure airport: Las Americas International Airport (SDQ)
  • Arrival airport: Tocumen International Airport (PTY)

Weather in Panama City

The best time to visit may depend on your preferred climate. In Panama City, the average temperature floats around 35ºC in the warmest months and 18ºC in the coldest ones. Keep this in mind when packing and planning any outdoor activities.

  • Highs: up to 35ºC
  • Lows: down to 18ºC
  • Hottest month: April
  • Coldest month: February
  • Driest month: February
  • Wettest month: October

How to save when flying from Santo Domingo to Panama City

A few tips for finding cheaper flights from Santo Domingo to Panama City:

  • Flexible dates: compare fares for two or three different departure days. Leaving a day earlier or later can make a noticeable difference to the price.
  • Baggage allowance: check what each fare includes before you book, so you aren't caught out by extra charges at the airport.
  • Airports on your route: confirm which airports you depart from and land at, especially if the city has more than one. This will help you plan your transfer and work out the total cost of getting around.

Looking for a bigger saving? Book a Flight + Hotel package to combine both in one booking and unlock exclusive discounts on your stay in Panama City. You can also save on a hire car by including it with your booking.

Frequently asked questions about flights from Santo Domingo to Panama City

On average, what is the price of a Santo Domingo to Panama City flight?
When flying from Santo Domingo to Panama City the average price will be €435. However, this price is dependant on several other factors like seasonality or the time in advance taken when booking the route.
For flights from Santo Domingo to Panama City, how can I find the cheapest price?
On eDreams we use machine learning to find the most economical flight between Santo Domingo and Panama City. By taking into account the combinations of airlines, stopovers, direct flights as well as the various criteria for the journeys, our search engine allows us to offer our customers the best price under the best conditions.
When booking, when is the best time to do so in order to get the best prices for Santo Domingo to Panama City flights?
The most popular month for flights from Santo Domingo to Panama City are: June, September and March.
When is the best time to travel from Santo Domingo to Panama City?
A good period of the year to visit Panama City from Santo Domingo really depends on lots of personal preferences, price being one of the main criteria When it comes to popularity, January is the best month to fly to Panama City from Santo Domingo, basedd on searches from our customers, followed by March and November. If you prefer to avoid the busy season and get away from the crowds May, August and July are the months with fewer searches for the route Santo Domingo -  Panama City.
What is the duration of a flight from Santo Domingo to Panama City?
Flight time, on average, from Santo Domingo to Panama City is usually 4 h and 35 m on average, at an average distance of 1,479.73 km, for flights for the route (which may have 1 or more stops in other cities in between).
What is the weather like in Panama City compared to Santo Domingo?
The average temperature in Santo Domingo is 27º degrees in summer. Panama City reaches 27º during the hot season. In winter, however, temperatures are around 26º degrees in Panama City, compared to the 25º average degrees in Santo Domingo.

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